 | G.Jesus | Knee injury - Unknown return date | | | Havertz | Hamstring injury - Expected back 01 Jun |
| | Tomiyasu | Knee injury - Expected back 01 Jun |
 | Enes Ünal | Knee injury - Unknown return date |
| | Smith | Muscle injury - Unknown return date |
 | Dasilva | Knee injury - Unknown return date |
| | Thiago | Knee injury - Unknown return date |
| | Carvalho | Shoulder injury - Expected back 25 May |
| | G.Nunes | Back injury - Unknown return date |
 | Igor | Hamstring injury - Expected back 01 Jun |
| | Milner | Hamstring injury - Unknown return date |
| | Steele | Shoulder injury - Unknown return date |
| | F.Kadıoğlu | Toe Injury - Expected back 25 May |
 | C.Doucouré | Knee injury - Expected back 01 Jun |
| | Chadi Riad | Knee injury - Unknown return date |
| | Ward | Unknown - Unknown return date |
 | Calvert-Lewin | Hamstring injury - Unknown return date |
| | Ndiaye | Knee injury - Unknown return date |
| | Mangala | Knee injury - Expected back 01 Jun |
 | Nelson | Hamstring injury - Expected back 25 May |
 | Burns | Knee injury - Expected back 01 Jun |
| | Tuanzebe | Hamstring injury - Unknown return date |
| | Muric | Shoulder injury - Unknown return date |
| | Szmodics | Ankle injury - Expected back 18 May |
| | Ogbene | Achilles injury - Expected back 01 Jun |
 | A.Fatawu | Knee injury - Expected back 01 Jun |
 | Bradley | Muscle injury - Unknown return date |
| | Gomez | Hamstring injury - Unknown return date |
| | Morton | Shoulder injury - Unknown return date |
 | Akanji | Muscle injury - Expected back 26 Apr |
| | Aké | Foot injury - Expected back 18 May |
| | Rodrigo | Knee injury - Expected back 01 Jun |
| | Stones | Thigh injury - Expected back 18 May |
 | Amad | Ankle injury - Unknown return date |
| | Bayindir | Knock - Unknown return date |
| | Evans | Muscle injury - Unknown return date |
| | Heaton | Knock - Unknown return date |
| | Mainoo | Knock - Unknown return date |
| | Martinez | Knee injury - Unknown return date |
| | Shaw | Knock - Unknown return date |
 | Botman | Knee injury - Expected back 03 May |
| | Hall | Foot injury - Expected back 01 Jun |
| | Lascelles | Knee injury - Expected back 25 May |
 | Bree | Hamstring injury - Unknown return date |
| | Smallbone | Groin Injury - Unknown return date |
 | Dragusin | Knee injury - Expected back 01 Jun |
| | Danso | Hamstring injury - Unknown return date |
 | Antonio | Leg injury - Unknown return date |
| | Summerville | Hamstring injury - Unknown return date |
 | Chiwome | Knee injury - Expected back 01 Jun |
| | Gonzalez | Knee injury - Unknown return date |
| | Kalajdžić | Knee injury - Unknown return date |
| | Mosquera | Knee injury - Expected back 01 Jun |
