Brentford will mark their first season in the Premier League with a home match against Arsenal on August 13, live on Sky Sports on Friday Night Football.
Championship play-off winners Brentford, who have not played in the top flight since the 1946/47 season, then face Crystal Palace at Selhurst Park in their first away game on August 21.
Thomas Frank’s side host west-London rivals Chelsea on October 16 before travelling to Stamford Bridge for the return fixture on April 2.
Brentford make the trip to Brighton on Boxing Day, while their first game of 2022 is at home to Aston Villa on New Year’s Day.
Brentford host Leeds United on May 23 to wrap up their debut Premier League campaign.
Brentford’s 2021/22 Premier League fixtures
All fixtures subject to change.
August
13: Arsenal (h) – 8pm, live on Sky Sports
21: Crystal Palace (a) – 3pm
28: Aston Villa (a) – 3pm
September
11: Brighton (h) – 3pm
18: Wolves (a) – 3pm
25: Liverpool (h) – 3pm
October
2: West Ham (a) – 3pm
16: Chelsea (h) – 3pm
23: Leicester City (h) – 3pm
30: Burnley (a) – 3pm
November
6: Norwich City (h) – 3pm
20: Newcastle United (a) – 3pm
27: Everton (h) – 3pm
December
1: Tottenham Hotspur (a) – 7.45pm
4: Leeds United (a) – 3pm
11: Watford (h) – 3pm
14: Manchester United (h) – 7.45pm
18: Southampton (a) – 3pm
26: Brighton (a) – 3pm
28: Manchester City (h) – 3pm
January
1: Aston Villa (h) – 3pm
15: Liverpool (a) – 3pm
22: Wolves (h) – 3pm
February
9: Manchester City (a) – 8pm
12: Crystal Palace (h) – 3pm
19: Arsenal (a) – 3pm
26: Newcastle United (h) – 3pm
March
5: Norwich City (a) – 3pm
12: Burnley (h) – 3pm
19: Leicester City (a) – 3pm
April
2: Chelsea (a) – 3pm
9: West Ham (h) – 3pm
16: Watford (a) – 3pm
23: Tottenham Hotspur (h) – 3pm
30: Manchester United (a) – 3pm
May
7: Southampton (h) – 3pm
15: Everton (a) – 3pm
22: Leeds United (h) – 4pm
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Key dates for the 2021/22 season
The 2021/22 Premier League will start on Saturday August 14 – 34 days after the Euro 2020 final at Wembley.
The season will end on May 22 2022, with all 10 games kicking off at the same time.
The 2021/22 EFL season will kick-off on Saturday August 7.
Next season’s League One campaign will finish on the weekend of April 30 2022, with League Two and the Championship on one of May 7 and May 8 respectively.
The League One play-off final will then be held on Saturday May 21, the League Two play-off final on Saturday May 28, and the Championship play-off final on Sunday May 29.